Most tumors in children are functional, and virilization is by far the most common presenting symptom(s), followed by Cushing's syndrome and precocious puberty. Signs and symptoms Īdrenocortical carcinoma may present differently in children and adults. The widely used angiotensin-II-responsive steroid-producing cell line H295R was originally isolated from a tumor diagnosed as adrenocortical carcinoma. It has a bimodal distribution by age, with cases clustering in children under 5 and in adults 30–40 years old. Īdrenocortical carcinoma is a rare tumor, with incidence of one to two per million population annually. Adrenocortical carcinoma has often invaded nearby tissues or metastasized to distant organs at the time of diagnosis, and the overall 5-year survival rate is about 50%. H&E stain.Īdrenocortical carcinoma (ACC) is an aggressive cancer originating in the cortex ( steroid hormone-producing tissue) of the adrenal gland.Īdrenocortical carcinoma is remarkable for the many hormonal syndromes that can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization, and feminization. Benign adrenal medulla is present (right-middle of image – gray/blue). Micrograph of an adrenocortical carcinoma (left of image – dark blue) and the adrenal cortex it arose from (right-top of image – pink/light blue). Medical condition Adrenocortical carcinomaĪdrenal cortical carcinoma, adrenocorticocarcinoma, adrenal cortical cancer, adrenal cortex cancer
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